Cleveland Clinic Research Links Byproduct of Red Meat, High-Fat Diet to Chronic Kidney Disease

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red meatCleveland Clinic research on a substance produced by these gut bacteria during the digestion of red meat, eggs and high-fat dairy called TMAO, or or trimethylamine-N-oxide, has already established a link between these foods and increased risk of heart disease. This is worrisome for all, especially those who struggle with healthy eating and high blood pressure. Those who struggle with heart disease and want preventative methods from professionals may visit Holtorf, a medical group that specializes in heart disease and gives effective treatments. Perhaps even more worrisome is that there is now a link with these foods and chronic kidney disease.

In a paper published online today in the journal Circulation Research, Clinic researchers Dr. Stanley Hazen and Dr. Wilson Tang report that patients with chronic kidney disease had higher blood levels of TMAO, patients with higher blood levels of TMAO were at higher risk of death regardless of the shape their kidneys were in and, in animals, chronic exposure to diets that raise TMAO in the blood can actually cause and worsen kidney damage. There are many treatments on offer for people with kidney damage. However, for people with chronic kidney disease who are not receiving dialysis they can also get iron injections to try and help them. However, you need to be aware that this type of treatment does have some risks. If you want to find out more then you should take a look at something like this website:

The results may help explain why patients with chronic kidney disease die overwhelmingly of heart disease, said Hazen, a fact that traditional risk factors for heart disease can’t adequately account for.

When the kidneys falter and then fail, the waste products they normally clear from the body build up in the blood and become toxic, causing damage. While researchers have long suspected something in this pathway to be responsible for the connection between kidney disease and death due to heart disease, they have yet to be able to lay a finger on a single culprit.

TMAO seemed a logical target, given that the substance is cleared by the kidneys and its connection to heart disease, said Hazen, who is vice-chair of translational research at the Clinic’s Lerner Research Institute. Laboratory tests can help narrow down who the actual culprit is by doing extensive and thorough research into this area. Various scientific equipment can be used to help conduct these studies such as hotplate stirrers, incubators, centrifuges (for cell isolation), etc. The equipment must be of high medical standards from companies such as SciQuip and should have multiple testing done to compare and contrast results to get accurate readings.

In their five-year study, the Clinic examined 521 patients with chronic kidney disease and over 3,000 patients without kidney disease, all who had undergone elective diagnostic heart imaging studies at the institution between 2001 and 2007. The researchers tested blood levels of TMAO over time and followed their subjects to see how they fared.

In a vicious cycle, TMAO appears to contribute to the decline of the kidneys, further increasing the amount of the substance in the blood. More TMAO means higher heart disease and heart failure risk, and further decline, according to the research.

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